Asymmetric and symmetric dimethylarginines and mortality in patients with hematological malignancies—A prospective study


M. Karczewski, M. Biedroń, A. Butrym, A. Chachaj, M. Krzystek-Korpacka, J. Rybka, A. Szuba, J. Wiśniewski, Asymmetric and symmetric dimethylarginines and mortality in patients with hematological malignancies—A prospective study, PLoS ONE 13 (5), (2018) . doi:10.1371/journal.pone.0197148
Karczewski M., Biedroń M., Butrym A., Chachaj A., Krzystek-Korpacka M., Rybka J., Szuba A., Wiśniewski J.,


The study was designed to determine the associations of asymmetric (ADMA) and symmetric (SDMA) dimethylarginines plasma concentrations with all-cause mortality in patients with hematological malignancies. 33 patients with acute myeloid leukemia (AML), 31 patients with non-Hodgkin’s lymphoma (nHL), 32 patients with chronic lymphocytic leukemia (CLL) and 48 patients without malignancy were enrolled into the study. Each patient was followed until death or for at least 14.5 months (range: 14.5-53). Median ADMA and SDMA were significantly elevated in AML, nHL and CLL compared to controls (ADMA: 1.36, 1.24, 1.03, 0.55 mu mol/l respectively, p<0.0001; SDMA: 0.86, 0.76, 0.71, 0.52 mu mol/l respectively, p<0.0001). High ADMA and SDMA were associated with increased risk for all-cause mortality in CLL group (Hazard ratio (HR) for ADMA: 3.05, 95% CI:1.58-5.88, p = 0.001; HR for SDMA: 4.71, 95% CI:1.91-11.58, p = 0.001). Our study suggests that ADMA and SDMA could be novel prognostic factors for all-cause mortality in CLL patients.





The Faculty of Environmental Engineering and Geodesy

Institute of Environmental Engineering

Wrocław University of Environmental and Life Sciences

pl. Grunwaldzki 24,
50-363 Wrocław

Project assumptions

The overall goal of the project is to develop an innovative multifactor mathematical model enabling monitoring of bath contamination used in the electropolishing process of austenitic stainless steels. This model will allow optimization and reduction of process costs and will have an impact on reducing environmental pollution during electrolytic polishing of austenitic stainless steels.

The final outcome of the project will consist in the development of a method of monitoring the gradual contamination of the electropolishing bath.


The team deals with research in the field of electrochemistry, wastewater treatment, monitoring and optimization of processes in laboratory and industrial conditions. The diverse experience of individual members of the IonsMonit team is its strength.



Project: “A pioneering model for monitoring pollution of electropolishing process baths (IonsMonit)” financed by the National Center for Research and Development as part of the Lider programme.