Electrical bioimpedance as a diagnostic method for lipodystrophy syndrome in HIV-infected patients in lower silesia, poland

QUOTING:

M. Czarnecki, J. Drelichowska, J. Gąsiorowski, B. Knysz, W. Kwiatkowska, W. Witkiewicz, S. Manasterski, Electrical bioimpedance as a diagnostic method for lipodystrophy syndrome in HIV-infected patients in lower silesia, poland, HIV and AIDS Review 16 (2), (2017) 70-76. doi:10.5114/hivar.2017.66795
Czarnecki M., Drelichowska J., Gąsiorowski J., Knysz B., Kwiatkowska W., Witkiewicz W., Manasterski S.,

Abstract

Introduction: Despite a great progress in antiretroviral therapy (ARV) there are many human immuno-deficiency virus (HIV)-infected patients with lipodystrophy syndrome (LS). However, there are still no clearly defined criteria to diagnose dystrophic changes. It would be valuable to introduce a non-invasive and inexpensive method to clinical practice, which could objectify the assessment of LS in HIV-infected population. The aim was to determine usefulness of electrical bioimpedance in the diagnostics of lipodystrophy syndrome.

Material and methods: One hundred and ten HIV-infected patients, on antiretroviral therapy, were examined for the presence of LS. The control group included 42 healthy individuals. The study protocol included anthropometric measurements and bioelectrical impedance analysis (BIA). The measurements of BIA were interpreted using specific computer software. All parameters were subjected to a comparative analysis between the study group and the control group.

Results: HIV-infected patients had significantly higher percentage values of fat-free mass (FFM), total body water (TBW) and muscle mass (MM) than the control group. Fat mass (FM) and percentage content of fat tissue (FM%) was significantly lower in the study group. A linear relationship of FM, percentage content of fat-free mass (FFM%), percentage content of total body water (TBW%) and percentage content of muscle mass (MM%) upon the severity of LS in HIV-positive patients has been demonstrated. The most significant changes were observed in patients with lipoatrophy who had the lowest absolute and percentage values of FM and the highest values of FFM%, MM% and TBW%.

Conclusions: The results support the potential usefulness of BIA as a non-invasive and low-cost diagnostic method for LS. Parameters such as FM%, FFM%, and TBW% can be used to assess the severity of lipodystrophy. However, these parameters require a larger study population and continuation of research.

Contact

 

 

 

The Faculty of Environmental Engineering and Geodesy

Institute of Environmental Engineering

Wrocław University of Environmental and Life Sciences

Address:
pl. Grunwaldzki 24,
50-363 Wrocław

Project assumptions

The overall goal of the project is to develop an innovative multifactor mathematical model enabling monitoring of bath contamination used in the electropolishing process of austenitic stainless steels. This model will allow optimization and reduction of process costs and will have an impact on reducing environmental pollution during electrolytic polishing of austenitic stainless steels.

The final outcome of the project will consist in the development of a method of monitoring the gradual contamination of the electropolishing bath.

Team

The team deals with research in the field of electrochemistry, wastewater treatment, monitoring and optimization of processes in laboratory and industrial conditions. The diverse experience of individual members of the IonsMonit team is its strength.

 


 

Project: “A pioneering model for monitoring pollution of electropolishing process baths (IonsMonit)” financed by the National Center for Research and Development as part of the Lider programme.

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